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It depends on the size, age, breed and overall health. In general, one teaspoon every 6-8 hours for large dogs and 1/2 teaspoon every 6-8 hours for small dogs of the 15mg per 10ml strength. The dosage by weight is anywhere from .25mg to 1mg/pound. The vet started my older bichon at 1ml every 6 hours and we could go up to 3ml every 6 hours which is just over 1/2 teaspoon.

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