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Alcohol and benzodiazepine withdrawal are, by far, the most dangerous. Both of these substances bind GABA (gamma-amino-butyric acid), the major inhibitory neurotransmitter in the central nervous system. When GABA receives no more "stimulation" from alcohol or benzodiazepines (e.g. Xanax, Valium, Ativan, Klonopin, etc.) there is a significant imbalance between excitatory and inhibitory neurotransmission. Excitation of the neuronal system prevails, and withdrawal symptoms of hypertension, tachycardia, sweating, tremors and anxiety occur, and may be followed by seizures, and even coma and death, if left untreated.

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