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The major target of aldosterone is the distal tubule of the kidney, where it stimulates exchange of sodium and potassium. Three primary physiologic effects of aldosterone result:
- Increased resorption of sodium: sodium loss in urine is decreased under aldosterone stimulation.
- Increased resorption of water, with consequent expansion of extracellular fluid volume. This is an osmotic effect directly related to increased resorption of sodium.
- Increased renal excretion of potassium.
Knowing these effects should quickly suggest the cellular mechanism of action this hormone. Aldosterone stimulates transcription of the gene encoding the sodium-potassium ATPase, leading to increased numbers of "sodium pumps" in the basolateral membranes of tubular epithelial cells. Aldosterone also stimulates expression of a sodium channel which facilitates uptake of sodium from the tubular lumen.
What else can I help you with?
What is the purpose of an aldosterone assay?
Aldosterone measurement is useful in detecting a condition called aldosteronism, which is caused by excess secretion of the hormone from the adrenal glands. There are two types of aldosteronism: primary and secondary.
What is the roleof aldosterone?
Aldosterone will cause Na+ to be absorbed from a filtrate
What is the role of aldosterone?
Aldosterone promotes water retention and reduces urine volume
How does dehydration affect aldosterone secretions?
It decreases the affect of aldosterone secretion.
How to increase aldosterone?
Aldosterone is primarily regulated by the renin-angiotensin-aldosterone system. To increase aldosterone levels, factors that can stimulate its production include low blood pressure, low blood volume, high potassium levels, and high Angiotensin II levels. These conditions can trigger the release of aldosterone from the adrenal glands.
How does aldosterone get to the kidneys?
Aldosterone is a hormone, so it gets to the kidneys via the blood stream.
The main site of aldosterone synthesis is?
The main site of aldosterone synthesis is in the zona glomerulosa of the adrenal cortex. Aldosterone production is regulated by the renin-angiotensin-aldosterone system, which responds to changes in blood pressure and electrolyte balance.
What happens when Aldosterone increases?
Aldosterone causes sodium to be retained and potassium to be excreted and blood pressure to rise.
Which area is sensitive to aldosterone?
Aldosterone is sensitive to a few different things. The main thing it is sensitive to is the kidneys.
Does pituitary gland secretes aldosterone?
No, the pituitary gland does not secrete aldosterone. Aldosterone is primarily secreted by the adrenal glands, specifically by the outer layer called the adrenal cortex. The hormone aldosterone plays a key role in regulating blood pressure and electrolyte balance in the body.
What is the major mineralocorticoid?
Aldosterone
What is the abbreviation of aldosterone?
ADT
