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Demerol and any other opiate overdose can be reversed by Naloxone (Narcan), as it is the preferred opiate blocker for all opioid overdoses.

HOWEVER...

Demerol is different from other opioids in that it also produces a metabolite that is toxic (norpethidine) that is not eliminated by the Narcan. So depending on the amount ingested or if it has been chronically used, eliminating the CNS depressant effects of the Demerol by administering Narcan allows the norpethidine to predominate and can cause even more dangerous convulsions and seizures.

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