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Hey there!

This right here is a very interesting question, so thank you for asking.

The technology used here is recombinant genome technology where scientists use plasmids with genes from the virus which will only code the outer shell but not let it have any of its proteins that will make it lethal. In other words, they make the virus unarmed to cause a serious infection. Also, there should be a specific cell line to help you produce such VLPs.

But before that, the scientist must know the genome construct of the virus, how its genome is organised, how the genes are expressed and who does the virus relate to. Once they know that, they can do the above, but believe me, it can involve a lot of trial and error and reading many papers to get ideas on how to make such an experiment successful.

I can give one great example, the making of the third type of polio vaccine using the VLP technology where the virus is just an empty husk and lacking an entire genome.

Hopefully, I was able to answer your question! 😄

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Viral_TDM

Lvl 7
∙ 4y ago

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