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What is the reported UV lambda max of Vildagliptin drug?
The reported UV lambda max of Vildagliptin drug is 254 nm.
What is the difference between valdagliptin and citagliptin?
Both are antidiabetic drugs. Sitagliptin's commercial name is Januvia (Merck- MSD) . Vildagliptin's commercial name is Galvus (Novartis) which is in the market in the EU but not in the US.Vildagliptin is C17H25N3O2 : (2S)-{[(3-Hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrileSitagliptin is C16H18F65O5P : (R)-3-Amino-1-[3-(trifluormethyl)-5,6,7,8-tetrahydro[1,2,4]triazol[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifFrom Wikipedia:Vildagliptin (previously identified as LAF237, trade name ZOMELIS) is an oral anti-hyperglycemic agent (Anti-diabetic_drug) of the new DPP-4_inhibitorsclass of drugs. Vildagliptin inhibits the inactivation of Glucagon-like_peptide-1and Glucose-dependent_insulinotropic_peptideby DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas.Vildagliptin has been shown to reduce hyperglycemia in Type_2_diabetes_mellitus.Novartis has since withdrawn its intent to submit vildagliptin to the FDA, as of July 2008. The Food_and_Drug_Administrationhad demanded additional clinical data before it could approve vildagliptin including extra evidence that skin lesions and Kidneyimpairment seen during an early Clinical_trialon animals have not occurred in human trials.While the drug is still not approved for use in the US, it was approved in Feb 2008 by European_Medicines_Agencyfor use within the EU and is listed on the Australian PBS with certain restrictions.Sitagliptin (International_Nonproprietary_Name; previously identified as MK-0431 and sold under the trade name Januvia) is an oral antihyperglycemic (Anti-diabetic_drug) of the DPP-4_inhibitorsclass. It was developed and is marketed by Merck & Co. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as Metforminor a Thiazolidinedione) for treatment of Diabetes_mellitus_type_2.Special:WysiwygThe benefit of this medicine is its lower side-effects (e.g., less hypoglycemia, less weight gain) in the control of blood glucose values. Exenatide(Byetta) also works by its effect on the Incretinsystem.
