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Usually, a form of granulocyte-colony stimulating factor (G-CSF) is given to a patient intravenously or subcutaneously either the night before or the day of the scheduled previous apheresis for a period of time depending on the clinical scenerio and goal. G-CSF comes under several trade names such as Neupogen, Granocyte or Neulasta. The goal is to stimulate the bone marrow to produce stem cells thereby re-establishing the bone marrow cell population after therapy in some diseases such as aplastic anemia or to increase the yield of these stem cells for collection by apheresis for later use in rebuilding the marrow following chemotherapy for leukemias and/or lymphomas.

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