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Most antidepressants cause weight gain, however Prozac is known to cause weight loss in some people which is why it is also prescribed for obesity.

AnswerWeight loss is a known side effect of Wellbutrin (bupropion) products. In some people, Prozac (fluoxetine) can cause mild weight loss at the beginning of treatment. Weight loss is possible with other SSRI's as well as Effexor and Cymbalta, however they also have the potential to cause weight gain. It depends on how your body responds to the drug.
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12y ago

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