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The only difference between these two pills is the amount of acetaminophen (Tylenol) contained within. As to which one is more effective, it can depend on what kind of pain you have. If it is an 'inflammatory' type of pain that Tylenol works really well against, more Tylenol (10/500) would be better. On the other hand, some people report that the hydrocodone is more effective with less Tylenol, and prefer the 10/325 combination instead. I believe the phrase "More killer, less filler" is used to express this preference :)

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