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Edward Jenner created the first vaccine to be widely used in 1796; others had done the same before him, but their discoveries were not well-known. Jenner found that milkmaids infected with cowpox did not get smallpox. He tested this theory on a young boy, first exposing him to cowpox, then smallpox. The boy did not develop smallpox, and Jenner's work was published widely.

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