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Humans are unable to make their own folate. Folate is necessary for the production of DNA and RNA so humans must eat folate produced by other organisms which is why humans are unaffected by the action of sulphonamides.

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How Sulfonamides work on human body?

Sulfonamides are a class of antibiotic - the first class of useful antibiotic, in fact. They work by inhibiting the production of folate by bacteria. Because humans cannot make their own folate (we must eat folate produced by other organisms), sulfonamides do not affect human cells. Folate is necessary for the production of DNA and RNA, so inhibiting its production in bacterial cells stops the bacterial cells from dividing. Because sulfonamides to not directly kill the bacteria, only stop their spread, they are called bacteriostatic.


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Sulfonamides are a type of antibiotic commonly used to treat bacterial infections such as urinary tract infections, respiratory tract infections, and skin infections. They work by inhibiting the growth of bacteria by blocking their ability to produce folic acid, which is essential for their survival. It is important to note that sulfonamides are not effective against viral infections.