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Adderall causes receptors on your neurotransmitters to "stand up" causing an increase of dopamine and seratonin absorption in your body. When adderall wears off these receptors start to bend over again and your nerves are not being stimulated as much causing a temporary feeling of tiredness until your body readjusts to the lower amount. Adderall also increases your heart rate so when it wears off blood is being pumped slower through your body and less oxygen is reaching your muscles, so they feel tired as well until they readjust. In addition, Adderall is a catabolic drug, which basically means that it requires your body to use more energy, so your body is also receiving less energy when it wears off. Not too much to worry about from a physical standpoint, this phenomena is more commonly refered to as a "crash." However, if you have been taking Adderall for a while and the effects of the crash have not lessened you might want to consider talking to your prescriber about lowering your dosage.

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