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Amlodipine can interact with digoxin primarily due to its effects on the body's metabolism and cardiovascular system. Amlodipine may increase the plasma concentration of digoxin by affecting renal clearance and altering hemodynamics, potentially leading to digoxin toxicity. Additionally, both medications impact heart rate and contractility, which can compound their effects and increase the risk of adverse reactions. Therefore, careful monitoring is essential when these drugs are used together.

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1mo ago

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