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A random mutation in one bacteria can result in this.

think of a huge population of bacteria. billions of bacteria. and only 5 or so have the resistance by a random chance (random mutation).

the antiobiotics will kill all of bacteria, except for the 5 with the resistance.

Then, only those 5 will reproduce. since they reproduce asexually, this resistance will be passed on to all of the daughter. Then, all of sudden, there are a lot of bacteria around that are resistant to the antibiotic...

it can also occur by conjugation, which is when a bacteria inserts its DNA into another bacteria. this can result in the second bacteria having the resistance too.

this is a very basic description of the process.

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