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the terminal end of the colon is not acidic. in fact, as you go from the stomach-small intestine-colon, the pH gradually increases from 2 to around 8. Amphetamines salts (like the ones in Adderall) are weakly basic and have a pka of around 6.6. because of this, most of the drug will be in an unionized form (will not have a charge on the amine in the structure) which makes it very hydrophobic (fat loving/favorable). Because of this, the amphetamines do not have a problem passing through the cells lining the colon. This, along with the enormous amounts of capillaries underlying the colon endothelial cells will allow for a fast, and very good permeability into the systemic circulation. Also to note-this route by passes 1st pass metabolism( the process of the drug going from the intestine to liver for excretion/modification of drug), thus you get mostly all of the amphetamines into your system without any of it being hindered/excreted by the liver.
What else can I help you with?
What is the route of drug administration from slowest to fastest?
Slowest or LEAST EFFECTIVE route to MOST EFFECTIVE route: Topical (Slowest or least effective) Ingestion Intramuscular (IM) Intraperitoneal Inhalation (Inhaler or ET tube) Intravenous (IV) Some studies show administration of drugs via ET tube is as effective as IV.
If a patient is vomiting and IV antiemetics are not available what other route could be considered?
rectal administration is possible. Compazine, I believe, is one that can be. Scopalamine is sometimes administered in a patch form, too.
Is oral route of administration safer?
Yes the oral route for drug administration is the safest route.
What is the medical term meaning administration of a medication by injection?
Parenteral refers to any route of administration that bypasses the gastrointestinal tract. These routes can include Intravenous therapy (IV therapy), intramuscular/ subcutaneous/intradermal injection, buccal, sublingual, or rectal administration, or transvaginal administration (as with the vaginal contraceptive or hormone-therapy ring). Medication patches are also parenteral.
What kind of administration is introducing drugs into the gastrointestinal tract?
The oral route of administration.
Which of the is not a gi tract route of drug administration?
Topical administration is not a gastrointestinal tract route of drug administration. It involves applying medication directly to the skin or mucous membranes for localized effects.
Is mouthwash chloherxidine route of administration topical?
yes
What is a route In medical terms?
Usually used in connection with how a medication is given into the body, as the oral route, the intramuscular or intravenous route of administration.
Will oxycodone effect you more if you take the drug rectally?
No. The absorption of any opiate depends on the form (liquid/solid/gas) and the route of administration (oral, intravenous, rectal, inhaled). While there are some advantages of certain routes of administration which bypass initial degradation by the liver, for the most part rectal administration (ie "up the butt") is not likely to lead to higher or quicker blood levels. IF you wanted to have greater rectal absorption, I would suggest a liquid, an opiate with greater absorption characteristics (fentanyl, for example) and prolonged contact time (holding an enema for example). This still has the dangers of overdose (death or respiratory depression with aspiration) since it is hard to judge the effect in advance. I would suggest sticking to swallowing your oxycodone.
What is the route of administration of a drug that is placed between gum and cheek?
buccal
What route of administration has the quickest onset of action?
Intravenous
Can epinephrine be given endotracheal tube?
Yes, epinephrine can be administered through an endotracheal tube if intravenous access is not readily available in emergency situations. However, it is not the preferred route of administration and may not be as effective as intravenous or intramuscular routes.
