Why take at bedtime Simvistatin?

Answer 1

Since the body produces most of its cholesterol while sleeping, taking statins at night makes them most effective at blocking cholesterol production throughout the night. However, certain statins like atorvastatin (Lipitor) and rosuvastatin (Crestor) stay in the body for longer than the other statins, so they can generally be taken at any time of day. Also, lovastatin (Mevacor) should be taken with food in order to be sufficiently absorbed.

Answer 2

Simvastatin, along with the other drugs in the same class as it known as "statins", work by inhibiting HMG-CoA reductase, which is the enzyme responsible for making cholesterol. The majority of cholesterol synthesis occurs during sleep, thus why the "statins" are recommended to be taken at night.

Answer 3

Simvastatin is taken at night in order to allow the liver and kidneys time to filter the drug out without any other insults.

Side Note:Additionally, the drugs mechanism is inhibited by grapefruit juice, so avoid grapefruit juice while taking this medication

Serum cholesterol concentrations tend to be higher at night. Tests show that the medicine generally more effective when taken before nighttime sleep.