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Observational and non-interventional trials are related but not identical concepts. Observational trials involve monitoring participants without manipulating any variables or treatments, focusing on how outcomes occur in real-world settings. Non-interventional trials, on the other hand, may include observational designs but can also encompass other study types that do not involve active intervention by researchers, such as registry studies. In essence, all observational trials are non-interventional, but not all non-interventional trials are strictly observational.

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