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Colonial settlement significantly impacted Native American populations through the introduction of new diseases, which decimated communities that had no immunity. Additionally, land displacement and resource depletion due to agriculture and settlement led to conflicts and a loss of traditional hunting and gathering practices. This disruption of their way of life resulted in social upheaval, cultural erosion, and significant population decline, fundamentally altering Native American societies. Overall, the consequences of colonial expansion were devastating and long-lasting for Indigenous populations.

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