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Epidemics among Native American populations, such as smallpox and measles, significantly reduced their numbers and weakened their societies, making them less able to resist European colonization and exploitation. As the indigenous workforce dwindled, European settlers turned increasingly to the transatlantic slave trade to meet labor demands, particularly in agriculture and plantation economies. This shift led to a dramatic increase in the importation of enslaved Africans, as they were seen as a more stable and controllable labor source. The combination of declining Native populations and rising European demand for labor ultimately fueled the expansion of the slave trade.

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