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Western settlement often led to the displacement of Native American tribes from their ancestral lands. As settlers moved westward, they encroached on territories that Indigenous peoples relied on for their livelihoods, leading to conflicts and forced removals. Policies such as the Indian Removal Act facilitated this process, resulting in significant loss of land and culture for Native Americans and altering the demographic and social landscape of the region. This expansion was driven by the belief in Manifest Destiny, which justified the belief that Americans were destined to expand across the continent, often at the expense of its original inhabitants.

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