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The lack of immunity to diseases brought by European colonizers had devastating effects on Native American peoples, leading to widespread epidemics that decimated their populations. Illnesses such as smallpox, influenza, and measles spread rapidly, often wiping out entire communities and disrupting social structures. This loss of life significantly weakened their ability to resist colonization and contributed to the loss of land and cultural heritage. The demographic collapse also led to increased vulnerability to exploitation and violence from colonizers.

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