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While Tuberculosis is a serious, contagious, and potentially deadly disease if left untreated. In is not as serious as the black death, which is commonly believed to have been a strain of Y. pestis bacteria. Tuberculosis, even when transmitted, often results in a latent, asymptomatic form that does not lead to active infection, and among the actively infected the progress of the disease is much slower than plague.

Y. pestis, in comparison, which causes bubonic, septicemic, and pneumonic plague, can kill up to two of every three infected without treatment and can cause death with days. The major outbreaks of plague are among the worst pandemics in human history.

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