The donner and acceptor synthons in retrosynthsis?

Answer 1

In retrosynthesis, donor and acceptor synthons are conceptual fragments that help in planning the synthesis of a target molecule. Donor synthons are typically electron-rich sites or nucleophiles, while acceptor synthons are electron-poor sites or electrophiles. By identifying these fragments, chemists can work backwards from the target molecule to determine strategic disconnections, guiding the selection of starting materials and reaction pathways. This approach enhances the efficiency and predictability of synthetic routes.