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The action of Napoleon that caused the greatest human loss was his ill-fated invasion of Russia in 1812. The campaign, marked by extreme weather conditions, supply shortages, and fierce resistance from Russian forces, led to the catastrophic retreat of the Grande Armée. Of the approximately 600,000 soldiers who began the invasion, only about 100,000 made it back to safety, resulting in a staggering loss of life and marking a significant turning point in the Napoleonic Wars.

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