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Three Indian tribes that settled in eastern North Carolina are the Tuscarora, the Pamlico, and the Croatan. The Tuscarora were known for their resistance against European colonization in the early 18th century. The Pamlico and Croatan tribes also inhabited the region, engaging in trade and various cultural practices before facing significant decline due to European settlement and disease. These tribes played a crucial role in the early history of the region.

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