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The death of Justinian the Great did not have a great impact on the empire. His succession was smooth. The empire was much more affected by an epidemic, which has been called the plague of Justinian because it occurred during his reign, which raged from 541 to 543 and decimated the population. This affected the economy of the empire severely and, combined with the expenses of Justinian's wars, emptied the coffers of the state. The army had to recruit soldiers from outside the empire. Justinian's successor, Justin, II, pursued unwise foreign policies which led to war with and defeat by the Persians, who overrun Syria..

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