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Settlers in the Southeast wanted the federal government to remove Native Americans from their lands to make way for agricultural expansion and settlement. They sought policies that would facilitate the relocation of tribes, often advocating for treaties that would cede Native American territories to the government. This desire culminated in the Indian Removal Act of 1830, which led to the forced relocation of thousands of Native Americans, most notably through the Trail of Tears. Settlers aimed to secure land for cotton cultivation and other economic opportunities, prioritizing their interests over the rights and sovereignty of Native American nations.

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