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Many Infectious Diseases such a small-pox that the natives or their ancestors had never encountered and therefore had no immunity to. Along with disease, they brought their culture such as a racial Caste System that placed he natives as slaves, the hybrids as middle-class citizens, and the pure Spaniards as nobles. AND the Catholic faith which they forced the natives to sign (the natives had no idea what they were signing). If the natives didn't they would be killed. That's a rough outline.

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