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Dirty Harry's line about the 44 Magnum being the most "powerful handgun in the world" has not been true for some time.

There are many handguns chambered in rifle calibers for hunting and long range shooting. These pistols, in calibers such as .308, 8mm, 30-06, etc, are far more powerful than the .44 Magnum.

In recent years, large bore revolvers have been made in very powerful calibers, such as the .460, 454 Casull, .500 S&W, etc. There are even a few special handguns that fire the 12 g shotgun shell.

However, a challenger for the title of the "world's most powerful handgun" may be the Maadi bolt action pistol, in caliber .50 Browning Machine Gun. Extremely heavy, large, expensive, and of limited usefulness- but powerful.

There is also a one of a kind custom pistol in .600 Nitro Express. There are videos online of a man shooting it where the recoil rips it right out of his and and flings it behind him.

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