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The Tuskegee Experiment, conducted from 1932 to 1972, involved a study of untreated syphilis in African American men in Alabama, where participants were misled into believing they were receiving free healthcare. It was initiated to observe the natural progression of the disease without treatment, under the guise of studying the effects of syphilis on health. The unethical nature of the study, which continued even after penicillin became a standard treatment, has led to widespread condemnation and significant changes in ethical standards for medical research.

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