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Within thirty years of Columbus's discovery of San Salvador in 1492, the most significant changes included the onset of European colonization and the drastic decline of indigenous populations due to disease, warfare, and enslavement. The arrival of Europeans led to the establishment of plantations and the exploitation of resources, fundamentally altering the social and economic landscape of the Americas. Additionally, the Columbian Exchange initiated the transfer of crops, animals, and cultures between the Old and New Worlds, reshaping diets and lifestyles on both sides of the Atlantic.

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