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The queen died in early February of 1458 B.C. In recent years, scientists have speculated the cause of her death to be related to an ointment or salve used to alleviate a chronic genetic skin condition. Thutmose III began a campaign to eradicate Hatshepsut's memory: He destroyed or defaced her monuments, erased many of her inscriptions and constructed a wall around her obelisks. While some believe this was the result of a long-held grudge, it was more likely a strictly political effort to emphasize his line of succession and ensure that no one challenged his son Amunhotep II for the throne.

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