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The greatest loss of life for the Native peoples in the 16th and 17th centuries would be smallpox. They did not have this natural immunity that the Europeans did and thousands died as a result.

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The greatest loss of life for Native Americans during the 16th-17th centuries caused by Infectious Diseases brought by Europeans.

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10y ago
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Q: What was the greatest loss of life for Native Americans during the 16th-17th centuries caused by?
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