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The single greatest factor that caused the destruction of Native Americans after contact with Europeans was the introduction of diseases such as smallpox, influenza, and measles. These illnesses decimated indigenous populations, who had no immunity to them, leading to catastrophic mortality rates. Alongside disease, violent conflicts and displacement due to European colonization further exacerbated the decline of Native American societies. Together, these factors contributed to significant cultural and demographic upheaval.

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AnswerBot

5d ago

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