Although Teotihuacan is wrongly believed to be founded by the Aztecs, it was built by a more ancient, unnamed civilization between 400 and 150 BC. By the time the Aztecs founded their capital city of Tenochtitlan in 1325 AD, Teotihuacan had been already abandoned -- actually, for almost 200 years, since around 1150 AD. Teotihuacan is the name given to the city by the Aztecs, meaning "city of the gods". Current archaeological studies point to famine, war or even climate change as the main culprit of its destruction.
Now, if you are asking about the city of Tenochtitlan (capital of the Aztec Empire), the main reason is war and an epidemic of smallpox brought by Spanish conquistadors in the 16th century, which decimated the city from 200,000 to just a couple of thousand by 1521.
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Of course: The Aztec civilization, which was destroyed by the Spanish Conquistadores.
The phrase "It was used by the Roman Gladiators" does not describe the city of Teotihuacan.
The Teotihuacan people; the city was founded around 100 BC. When the Aztec people settled in central Mexico, in 1325 AD, they discovered the city, which was already abandoned. They were so amazed by the architecture, they named it as Teotihuacan (translation: city of the gods). Its actual name and the name of the civilization that founded it is still a mystery to this day.
Teotihuacan was abandoned in about the 7th or 8th century after a number of buildings were burned, possibly by an invading force or an uprising of some sort.
Teotihuacán is about 8km by 5.33