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In Mesopotamia, the centers of civilization emerged primarily in the regions of Sumer, Akkad, Babylon, and Assyria. Key cities such as Ur, Uruk, and Babylon became significant due to advances in agriculture, trade, and governance. These urban centers were known for their monumental architecture, such as ziggurats, and contributed to developments in writing, law, and science, laying the foundation for subsequent cultures in the region.

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