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Jane Toppan, an American nurse in the late 19th century, is believed to have murdered at least 31 patients, although she claimed to have killed over 100. Her victims primarily included elderly patients, as well as members of her foster family, including her adoptive sister and her sister's children. Toppan used lethal doses of morphine and atropine to induce a state of euphoria before ultimately causing death. Her motive appears to have been a combination of a desire for control and a fascination with the effects of drugs on patients.

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