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The Amerindians of the Caribbean became the biggest losers primarily due to European colonization, which brought devastating diseases, warfare, and exploitation. The arrival of Europeans led to a dramatic decline in their populations, as they had no immunity to diseases like smallpox. Additionally, the imposition of forced labor systems and the destruction of their social structures further marginalized these indigenous communities. Consequently, their cultures and ways of life were severely disrupted, leading to near extinction.

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