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Early Spanish and French settlements in South Carolina failed primarily due to a combination of environmental challenges, conflicts with Indigenous populations, and lack of sustainable resources. For example, the Spanish established Charlesfort in 1562, but it struggled with food shortages and hostility from local tribes, leading to its abandonment. Similarly, the French attempted to establish a settlement at Fort Caroline in 1562, but faced similar difficulties, including disease and conflicts, ultimately resulting in their withdrawal from the region.

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