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The Spanish were successful in the Americas due to a combination of advanced military technology, such as firearms and steel weapons, and the use of horses, which gave them a significant advantage over indigenous populations. Additionally, they formed alliances with certain native groups who were rivals of the Aztecs and Incas, facilitating their conquests. The spread of diseases like smallpox also decimated indigenous populations, weakening resistance to Spanish colonization. Finally, the pursuit of wealth, particularly in gold and silver, motivated and funded their expeditions and settlements.

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