"¿Cuando es el cumpleaños de Manuel?" is Spanish for "When is Manuel's birthday?"
De vez en cuando
It means "When is Manuel's birthday?"
It means, "From when is this photo or [of] what?"
Comment est l'école de Manuel ? means "How is Manuel's school?" in English.
When do you go to your friend's house?
"When I go to see the new gold..."
It means: When is it two in the morning?
"Cuando es el cumpleaños de Ana" translates to "When is Ana's birthday" in English. It is a question asking for the date or details regarding Ana's birthday celebration.
Cuando los hombres hablan de mujeres was created in 1967.
when you look at your girlfriend's profile (or facebook wall, profile)
Manuel de Blas's birth name is Manuel de Blas Muoz.
Manuel de Juan's birth name is Manuel de Juan Guillot.