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The M6 fastener is metric and measures 6mm in diameter, while the 1/4-20 fastener is imperial and has a diameter of 1/4 inch with 20 threads per inch. M6 fasteners are compatible with metric hardware, while 1/4-20 fasteners are compatible with imperial hardware. M6 fasteners are commonly used in European machinery, while 1/4-20 fasteners are more common in American machinery.

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