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The opposition to and rejection of the League of Nations by the United States reflected a broader isolationist sentiment, leading to a reluctance to engage in international alliances or commitments. This stance influenced U.S. foreign policy in the lead-up to World War II, as the country initially focused on domestic issues and avoided direct involvement in European conflicts. The failure of the League to prevent aggression from totalitarian regimes further solidified the perception that collective security arrangements were ineffective, contributing to the U.S.'s delayed entry into the war until the attack on Pearl Harbor in 1941. Ultimately, this experience shaped the U.S.'s approach to post-war international organizations, leading to a more active role in the creation of the United Nations.

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