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insect spray contains chemicals (including many organophosphate compounds) that bind to and permanently block the action of an enzyme called acetylcholinesterase.

Acetylcholine (ACh) is the nerve transmitter substance released by motor neurons (at a site called the neuromuscular junction) to stimulate muscle contraction.

The muscles relax (stops contracting) when the ACh is removed from the neuromuscular junction (NMJ) by the action of acetylcholinesterase.

By inhibiting the cholinesterase the insect can no longer break down ACh in the NMJ and so its muscles lock up in a state of tetany (continuous contraction) making respiration impossible.

layman terms : its like nerve gas to an insect

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15y ago

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