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Currently, control of malaria vectors relies almost entirely on indoor residual-spraying (IRS) and long-lasting insecticide-treated nets (LLINs. These vector control tools have successfully reduced mosquito population densities and malaria by targeting indoor-feeding (endophagic) and indoor-resting (endophilic) mosquitoes. The most successful IRS chemical active used to date is DDT, which, in addition to killing mosquitoes, also reduces indoor mosquito densities consequently reducing malaria transmission.

Literature shows that much of the success of DDT is due to excito-repellency. An excito-repellent is defined as a chemical that causes insects to make undirected movements that set them apart from insecticides. Excito-repellency results from insect's physical contact with chemicals on treated surfaces or with vapour particles at a distance . It has been demonstrated that volatile DDT can induce neural excitement in insects and importantly, it was observed that insects exposed to sub-lethal concentrations of DDT move towards the light explaining why mosquitoes are likely to quickly leave a sprayed dwelling. Excito-repellency was also originally seen as a beneficial feature of pyrethroid treated bednets to reduce the probability of mosquitoes developing resistance to insecticides through lower contact with insecticides. It is known that DDT and pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve cell membranes, disrupting transmission of nerve impulses thereby causing mortality. Cross resistance between DDT and pyrethroids is conferred by point mutations on the voltage gated sodium channel in mosquitoes indicating a common mode of toxic action for these insecticides on mosquitoes.

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