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Some of the most well understood viruses are those that infect bacteria (bacteriophages, or phages for short). One such example is the T4 phage. This virus manages to stop production of the host cell's own proteins through modification of the enzymes responsible for production of host cell mRNA*1. It does this by using the cell's enzymes to produce proteins encoded on the virus' DNA. These proteins then bind the the cell's RNA polymerase*2 which renders them unable to recognise the cell's own promotors*3 while still being able to recognise the viral DNA's promotors. The viral DNA now has control over the cell's machinary and uses it to express proteins that assist replication of the viral DNA, and proteins into which it can package this DNA to make full virus particles.

not sure of your existing level of understanding, but just in case here's a little glossary of a few terms I've used:

*1 mRNA - short for messenger RNA, this is essentially the blueprint for production of proteins and enzymes, which has been noted down from the master plans stored in the DNA

*2 RNA polymerase - this is the enzyme responsible for production of the mRNA - it is essential to transmission of information stored in the DNA, and the resultant production of protein and enzymes

*3 promotors - these are basically like neon signs for genes within the DNA (a gene encodes the information for making a protein) saying "Take my plans - Make my protein!!". When these are switched on the RNA polymerase will take down the information and protein production can begin. If the promotor cannot be recognised by the RNA polymerase no production of that protein can be undertaken.

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13y ago

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