Its biggest weakness is its summoning condition, being that you first need to summon Blue-Eyes Ultimate Dragon. When you do summon it, it is also easily dealt with by non-targetting effects, like Mirror Force, Lightning Vortex, Smashing Ground, etc.
In the Superman mythology, green Kryptonite is a weakness for Superman while blue Kryptonite does not affect him, other Kryptonians or humans but it is a harmful source for Bizzaro, in another continuity it will cause Bizarro beings that are Kryptonian to become highly intelligent which scare them. In the Smallville show, the difference between the two is that both Green and Blue Kryptonites are a weakness for Clark Kent but Blue will take away his powers as long as he's near it for any length of time whereas Blue Kryptonite will overload Bizarro's power to the point that he will blow up.
She had a weakness for chocolate.We shall use our enemy's weakness against them.He felt a weakness in the knees.The interviewer asked me what my biggest weakness was.
Its weakness is gasoline
what is Orpheus' weakness
i have no idea what her weakness was
His weakness was his hair.
Goddesses do not know weakness. In listing a weakness, the label reveals more of the individual then that of a deity.
grass is his only weakness
Thinking about weakness is my weakness
ground type
the weakness of a monkey is food