That's a very vague question. If you mean a .22 caliber rifle, the techincal answer is, almost anything. It's possible for a .22 to kill almost any animal, it just isn't extremely likely in some cases.
You Kill Me was released on 06/22/2007.
You Kill Me was created on 2007-06-22.
I killed a raccoon with my 22'
Puppets Who Kill ended on 2006-06-22.
The Kill Point was created on 2007-07-22.
A View to a Kill was created on 1985-05-22.
To Kill with Intrigue was created on 1977-07-22.
You use a 22. rifle
None
Taggart - 1983 Cause to Kill 22-5 is rated/received certificates of: Netherlands:12
It will kill someone
All guns have the capacity to inflict death. It all depends on where the person was shot, but yes, even a small caliber like the .22 can easily kill someone.