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Absolutely. Phentermine and Ativan work on different neurotransmitters. Benzodiazepines create a calm effect by working through GABA. Phentermine, however, works on the neurotransmitters norepinephrine and dopamine. In fact, benzodiazepines are administered in cases of amphetamine overdose. However, a combination to avoid may be pain killers and phentermine, as they both work on the neurotransmitter dopamine. This may produce a "speedball" effect.

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