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In 1970's the people used Intravenous saline water with barbiturates & paralytic . But now in most states three separate injections (in sequential order) are used : # Sodium thiopental: ultra-short action barbiturate, an anaesthetic agent capable of rendering the offender unconscious in a few seconds. # Pancuronium: non-depolarizing muscle relaxant, causes complete, fast and sustained paralysis of the skeletal striated muscles, including the diaphragm and the rest of the respiratory muscles; this would eventually cause death by asphyxiation. # Potassium chloride: stops the heart, and thus causes death by cardiac arrest. The drugs are not mixed externally as that can cause them to precipitate

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